Chicago firefighters battled the fire at Carnitas La Michoacana, 2049 W. Cermak Road, on the Southwest Side.
Flames poured from the back of the building before the roof collapsed.
Several workers were treated for smoke inhalation, and two were taken to a hospital.
Two people were injured and a favorite neighborhood restaurant was lost after a fire broke out in Pilsen on Tuesday afternoon.
The fire started at 12:20 p.m. at a restaurant located at 2047 W. Cermak Rd., according to the Chicago Fire Department. Two people were taken to the hospital with smoke inhalation and listed in good condition.
The restaurant, Carnitas La Michoacana, a popular neighborhood staple well known for its pork dishes, was destroyed by the blaze.