Chopper 6 was over Route 70 Friday, just east of Troth Road in Medford.
There, shortly after 6 p.m., police say a car and SUV collided, resulting in the closure of a short stretch of Route 70.
Five ambulances and a medical helicopter responded to the scene.
The injured victims were rushed to area hospitals for care.
Police have not identified the victims, or what caused the vehicles to collide.
The accident remains under investigation.