It happened around 10:20 p.m. Tuesday at County Line and Keith Valley roads.
A Honda sedan and a Honda SUV collided at the intersection.
Police arrived within minutes and worked to free the drivers.
Both victims were taken to Abington Hospital.
One driver was pronounced dead at the hospital.
The second driver suffered several injuries.
There is no information on the severity of that person's injuries.
Police shut down the intersection for several hours to investigate.