A state patrol dispatcher says all three were traveling in the same vehicle, which was struck by a tractor-trailer truck. Their names have not been released.
The crash remains under investigation.
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A fatal accident has closed Interstate 16 east in Treutlen County this morning.
Roxanne Carwell, a dispatcher at the Georgia State Patrol in Dublin, says the accident involved a car and a tractor trailer. Around 9:15, she said state patrol crews are still on the scene.
The accident happened near mile marker 72. The Georgia Department of Transportation says the highway may be closed until noon.
No further information was available.